§FMCSR.com
Historical textIn force on Oct. 1, 2006Source: annual CFR editions 2001–2007

§ 40.177 What does the second laboratory do with the split specimen when it is tested to reconfirm the presence of a drug or drug metabolite?

Wording first on file in the 2001 annual edition, superseded by the 2008 annual edition.

govinfo, 2006 edition ↗
Before Jan. 1, 2017 the record is one snapshot per annual CFR edition, revised as of October 1. This is the 2006 edition's wording. An amendment that took effect between Oct. 1, 2006 and Oct. 1, 2006 would not appear until the next edition, so check the citations below and the Federal Register for exact effective dates.
49 CFR § 40.177 — What does the second laboratory do with the split specimen when it is tested to reconfirm the presence of a drug or drug metabolite?. Text in force on October 1, 2006. This wording effective October 1, 2001 to October 1, 2008. Source: govinfo, 2006 edition, https://www.govinfo.gov/app/details/CFR-2006-title49-vol1/CFR-2006-title49-vol1-sec40-177. Retrieved from FMCSR.com, https://fmcsr.com/reg/40.177?asof=2006-10-01, on October 26, 2026. Unofficial compilation; verify against the official source.

(a) As the laboratory testing the split specimen, you must test the split specimen for the drug(s)/drug metabolite(s) detected in the primary specimen.

(b) You must conduct this test without regard to the cutoff concentrations of § 40.87 .

(c) If the test fails to reconfirm the presence of the drug(s)/drug metabolite(s) that were reported positive in the primary specimen, you must conduct validity tests in an attempt to determine the reason for being unable to reconfirm the presence of the drug(s)/metabolite(s). You should conduct the same validity tests as you would conduct on a primary specimen set forth in § 40.91 .

(d) In addition, if the test fails to reconfirm the presence of the drugs/drugs metabolites or validity criteria that were reported in the primary specimen, you may transmit the specimen or an aliquot of it to another HHS-certified laboratory that will conduct another reconfirmation test.

Amendment history

4 distinct wordings on file since Oct. 1, 2001
  1. June 1, 2023 → presenteCFR, day-precisediff vs. previous
    [65 FR 79526, Dec. 19, 2000, as amended at 73 FR 35972, June 25, 2008; 88 FR 27646, May 2, 2023]
  2. May 2, 2023 → June 1, 2023eCFR, day-precisediff vs. previous
    [65 FR 79526, Dec. 19, 2000, as amended at 73 FR 35972, June 25, 2008]
  3. Oct. 1, 2008 → May 2, 2023annual editions 2008–2016diff vs. previous
    [65 FR 79526, Dec. 19, 2000, as amended at 73 FR 35972, June 25, 2008]
  4. Oct. 1, 2001 → Oct. 1, 2008annual editions 2001–2007viewing

A new entry appears whenever the regulatory words change between government snapshots. Day-precise from the eCFR (2017 onward); before that, one snapshot per annual CFR edition (revised as of October 1). Bracketed citations are the Federal Register history printed with the section.